Medicines are occasionally prescribed for uses other than These shown in a very Medication Guide. Usually do not use Depakote for your ailment for which it wasn't prescribed. Do not give Depakote to other people, even if they've precisely the same signs or symptoms that you have. It could harm them.

serious multiorgan reactions. Cure with DEPAKOTE might lead to intense multiorgan reactions that may be lifetime-threatening or could bring on Demise.

Methotrexate could lessen serum valproate ranges and most likely lead to improved frequency of seizures or bipolar indicators. Prescribers really should observe serum valproate concentrations and scientific response when incorporating or discontinuing methotrexate and adjust valproate dosage, if needed.

No recommendation concerning the safety of valproate for use at doses earlier mentioned sixty mg/kg/working day is usually made. The probability of thrombocytopenia raises drastically at whole trough valproate plasma concentrations over a hundred and ten mcg/mL in ladies and 135 mcg/mL in males. The good thing about enhanced seizure Regulate with increased doses must be weighed towards the opportunity of a better incidence of adverse reactions.

Divalproex sodium dissociates to your valproate ion while in the gastrointestinal tract. The mechanisms by which valproate exerts its therapeutic consequences haven't been recognized.

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You'll be able to question your Health care provider or pharmacist for a listing of these medicines if you are not guaranteed.

Considering the fact that people had been also dealt with with other antiepilepsy medication, it can be not possible, normally, to determine irrespective of whether the subsequent adverse reactions is often ascribed to Depakote by yourself, or the combination of Depakote and also other antiepilepsy drugs.

In patients with epilepsy, a loss of seizure control may also occur. Individuals must be monitored carefully for visual appeal of those signs. Serum liver exams need to be carried out ahead of therapy and at Regular intervals thereafter, Primarily through the first six months [see WARNINGS AND Safety measures].

Standard of living outcomes weren't described in the provided experiments. *Rise in alanine transaminase/gamma-glutamyl transpeptidase

medication residue in the stool. Tell your healthcare provider When you've got or Assume you will have medicine residue as part of your stool.

reduced human body temperature (hypothermia). A fall in Your entire body temperature to under ninety five°File can occur all through treatment with get more info DEPAKOTE. Simply call your healthcare service provider In case you have any of the subsequent signs:

Using DEPAKOTE with other medicines can cause serious Unwanted side effects. Don't start or stop other medicines without the need of speaking to your healthcare provider. Especially convey to your Health care provider if you are taking:

The benefit of improved therapeutic outcome with greater doses really should be weighed versus the potential for a increased incidence of adverse reactions.